General notes:

55 Second Street is located between Market Street and Mission Street on Second Street in downtown San Francisco. The parking garage and loading dock are accessible from Anthony Street (off of Mission Street).

Second Street is a two-way street.
No left turns onto Second Street are permitted on Market Street.
No left turns onto Second Street are permitted on Mission Street.
Anthony Street is between First and Second Street (off of Mission Street).

EAST BAY:

Off the Bay Bridge, take the Fremont Street exit (the first San Francisco exit on the right side)
Turn left on Fremont Street
Turn left on Mission Street, just past the Transbay Terminal
Turn right on Anthony Street (an alley adjacent to Golden Gate University)
The parking garage entrance is on the left hand side of the street

SOUTH BAY:

US 101 North
Take the I-80 exit towards Bay Bridge/Oakland
Take the Fourth Street exit towards Embarcadero
Merge onto Bryant Street
Turn left on Second Street
Turn right on Mission Street
Take the first left turn onto Anthony Street
The parking garage entrance is on the left hand side of the street

NORTH BAY:

US 101 South across the Golden Gate Bridge
Follow 101 South (it will become Van Ness Avenue as it travels through the city)
Turn left on Bush Street (one block past Pine Street)
Turn right on Battery Street (at the end of Bush Street)
Cross Market Street and continue down what is now named First Street
Turn right on Mission Street
Turn right on Anthony Street
The parking garage entrance is on the left hand side of the street